SLC12A4 Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | Q9UP95 |
Reactivity | Human, Rat, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 120650 Da |
Gene ID | 6560 |
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Other Names | Solute carrier family 12 member 4 (Electroneutral potassium-chloride cotransporter 1) (Erythroid K-Cl cotransporter 1) (hKCC1) |
Dilution | WB~~WB 1:1000-2000, IHC 1:100-200 |
Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide. |
Storage Conditions | -20℃ |
Name | SLC12A4 (HGNC:10913) |
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Function | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells (PubMed:10913127, PubMed:34031912). May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Tissue Location | Ubiquitous (PubMed:8663127, PubMed:9516379). Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes (PubMed:9516379). This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS (PubMed:9516379). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.
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