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a-actinin Monoclonal Antibody(4A12)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P12814 |
| Reactivity | Human, Rat, Mouse |
| Host | Mouse |
| Clonality | Monoclonal |
| Calculated MW | 103058 Da |
| Gene ID | 87 |
|---|---|
| Other Names | ACTN1 |
| Dilution | IHC~~IHC 1:100-200 |
| Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide. |
| Storage Conditions | -20℃ |
| Name | ACTN1 |
|---|---|
| Function | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T- cell activation (PubMed:22689882). |
| Cellular Location | Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Cell membrane. Cell junction {ECO:0000250|UniProtKB:Q9Z1P2}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q7TPR4}. Note=Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle. Colocalizes with PSD in membrane ruffles and central reticular structures {ECO:0000250|UniProtKB:Q7TPR4} |
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Provided below are standard protocols that you may find useful for product applications.
Background
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
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