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GARP Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q14392 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 71979 Da |
| Antigen Region | 234-260 aa |
| Gene ID | 2615 |
|---|---|
| Other Names | Leucine-rich repeat-containing protein 32, Garpin, Glycoprotein A repetitions predominant, GARP, LRRC32, D11S833E, GARP |
| Target/Specificity | This GARP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 234-260 amino acids from the Central region of human GARP. |
| Dilution | IHC-P~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GARP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LRRC32 {ECO:0000303|PubMed:19651619, ECO:0000312|HGNC:HGNC:4161} |
|---|---|
| Function | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19651619, PubMed:19750484, PubMed:22278742). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:22278742). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:19651619, PubMed:19750484). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Cell surface |
| Tissue Location | Preferentially expressed in regulatory T-cells (Tregs). |
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
GARP is a type I membrane protein which contains 20 leucine-rich repeats.
References
Wang,R., PLoS ONE 3 (7), E2705 (2008)
Maire,G., Genes Chromosomes Cancer 37 (4), 389-395 (2003)
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$ 150.00
$ 385.00
Cat# AP6647c
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