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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > DCD Antibody (C-term)
DCD Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | P81605 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 11284 Da |
| Antigen Region | 74-103 aa |
| Gene ID | 117159 |
|---|---|
| Other Names | Dermcidin, 34--, Preproteolysin, Survival-promoting peptide, DCD-1, DCD, AIDD, DSEP |
| Target/Specificity | This DCD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 74-103 amino acids from the C-terminal region of human DCD. |
| Dilution | FC~~1:10~50 IHC-P~~1:50~100 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DCD Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DCD (HGNC:14669) |
|---|---|
| Function | [DCD-1]: Found in sweat, has an antimicrobial activity during early bacterial colonization (PubMed:11694882, PubMed:23426625). The secreted peptide assembles into homohexameric complexes that can associate with and also insert into pathogen membranes (PubMed:23426625). Once inserted in bacteria membranes forms anion channels probably altering the transmembrane potential essential for bacterial survival (PubMed:23426625). Highly effective against E.coli, E.faecalis, S.aureus and C.albicans (PubMed:11694882). Optimal pH and salt concentration resemble the conditions in sweat (PubMed:11694882). Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues (PubMed:17448443). |
| Cellular Location | Secreted [DCD-1]: Secreted. Membrane; Peripheral membrane protein. Membrane; Single-pass membrane protein. Note=The secreted peptide assembles into homohexameric complexes that can probably associate with pathogen membranes and also insert into these membranes where they behave as channels. |
| Tissue Location | Detected in urine (at protein level) (PubMed:25326458, PubMed:36213313, PubMed:37453717). Constitutively expressed in eccrine sweat gland cells (at protein level). Secreted into the sweat at a concentration of 1-10 micrograms/ml |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
DCD is a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients.
References
Todorov,P.T., J. Biol. Chem. 272 (19), 12279-12288 (1997)
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$ 150.00
$ 385.00
Cat# AP6718b
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