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KYNU Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q16719 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 52352 Da |
| Antigen Region | 359-386 aa |
| Gene ID | 8942 |
|---|---|
| Other Names | Kynureninase {ECO:0000255|HAMAP-Rule:MF_03017}, 3713 {ECO:0000255|HAMAP-Rule:MF_03017}, L-kynurenine hydrolase {ECO:0000255|HAMAP-Rule:MF_03017}, KYNU {ECO:0000255|HAMAP-Rule:MF_03017} |
| Target/Specificity | This KYNU antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 359-386 amino acids from the C-terminal region of human KYNU. |
| Dilution | FC~~1:10~50 IHC-P~~1:50~100 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | KYNU Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | KYNU {ECO:0000255|HAMAP-Rule:MF_03017, ECO:0000312|HGNC:HGNC:6469} |
|---|---|
| Function | Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. |
| Cellular Location | Cytoplasm, cytosol {ECO:0000255|HAMAP- Rule:MF_03017, ECO:0000269|PubMed:8706755} |
| Tissue Location | Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
KYNU is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. KYNU is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway.
References
Christensen,M., et.al., J. Inherit. Metab. Dis. 30 (2), 248-255 (2007)
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