Huntingtin (phospho Ser421) Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | P42858 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 347603 Da |
Gene ID | 3064 |
---|---|
Other Names | HTT; HD; IT15; Huntingtin; Huntington disease protein; HD protein |
Dilution | IHC~~Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications. |
Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide. |
Storage Conditions | -20℃ |
Name | HTT |
---|---|
Synonyms | HD, IT15 |
Function | [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function. |
Cellular Location | [Huntingtin]: Cytoplasm. Nucleus. Early endosome. Note=The mutant Huntingtin protein colocalizes with AKAP8L in the nuclear matrix of Huntington disease neurons. Shuttles between cytoplasm and nucleus in a Ran GTPase- independent manner (PubMed:15654337). Recruits onto early endosomes in a Rab5- and HAP40-dependent fashion (PubMed:16476778) |
Tissue Location | Expressed in the brain cortex (at protein level). Widely expressed with the highest level of expression in the brain (nerve fibers, varicosities, and nerve endings). In the brain, the regions where it can be mainly found are the cerebellar cortex, the neocortex, the striatum, and the hippocampal formation |
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Provided below are standard protocols that you may find useful for product applications.
Background
May play a role in microtubule-mediated transport or vesicle function.
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