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> home > Products > Primary Antibodies > Antibody Collections > Fc gamma R-mediated phagocytosis > GAB2 Antibody (N-term)
GAB2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | Q9UQC2 |
| Other Accession | Q9EQH1, Q9Z1S8 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 74458 Da |
| Antigen Region | 3-30 aa |
| Gene ID | 9846 |
|---|---|
| Other Names | GRB2-associated-binding protein 2, GRB2-associated binder 2, Growth factor receptor bound protein 2-associated protein 2, pp100, GAB2, KIAA0571 |
| Target/Specificity | This GAB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-30 amino acids from the N-terminal region of human GAB2. |
| Dilution | FC~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GAB2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GAB2 |
|---|---|
| Synonyms | KIAA0571 |
| Function | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. |
| Cellular Location | Cytoplasm. Cell membrane. Membrane raft {ECO:0000250|UniProtKB:Q9Z1S8} |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
GAB2 is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor.
References
Yamasaki,S., et.al., J. Biol. Chem. 276 (48), 45175-45183 (2001)
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$ 150.00
$ 385.00
Cat# AP6908A
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