- CITATIONS: 1
|Application ||IHC-P, FC, WB, E|
|Other Accession||P00481, O19072, P11725, Q9N1U7, P84010|
|Reactivity||Human, Mouse, Rat|
|Predicted||Bovine, Pig, Sheep|
|Calculated MW||39935 Da|
|Antigen Region||71-98 aa|
|Other Names||Ornithine carbamoyltransferase, mitochondrial, Ornithine transcarbamylase, OTCase, OTC|
|Target/Specificity||This OTC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-98 amino acids of human OTC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OTC Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Mitochondrion matrix.|
|Tissue Location||Mainly expressed in liver and intestinal mucosa.|
Provided below are standard protocols that you may find useful for product applications.
OTC is a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia.
Hansmannel,F., et.al., Neurosci. Lett. 449 (1), 76-80 (2009)
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