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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > C6 Antibody (N-term)
C6 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, FC, IHC-P, E |
|---|---|
| Primary Accession | P13671 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 104786 Da |
| Antigen Region | 30-58 aa |
| Gene ID | 729 |
|---|---|
| Other Names | Complement component C6, C6 |
| Target/Specificity | This C6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-58 amino acids from the N-terminal region of human C6. |
| Dilution | WB~~1:1000 IF~~1:10~50 FC~~1:10~50 IHC-P~~1:50~100 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | C6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | C6 {ECO:0000303|PubMed:2789218, ECO:0000312|HGNC:HGNC:1339} |
|---|---|
| Function | Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:22267737, PubMed:22832194, PubMed:26841837, PubMed:27052168, PubMed:30552328). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (PubMed:30552328). The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:30552328). Together with component C5b, involved in MAC complex assembly: complement C5b and C6 associate with the outer leaflet of target cell membrane, reducing the energy for membrane bending (PubMed:30552328, PubMed:32569291). |
| Cellular Location | Secreted. Target cell membrane; Multi-pass membrane protein. Note=Secreted as soluble protein (PubMed:2808363). Inserts into the cell membrane of target cells (PubMed:30552328, PubMed:31061395) |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
C6 is a component of complement cascade. It is part of the membrane attack complex which can insert into the cell membrane and cause cell to lyse. People with C6 deficiency are prone to bacterial infection.
References
Wu,C., et.al., Proteomics 7 (11), 1775-1785 (2007)
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$ 385.00
$ 150.00
Cat# AP6937a
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