DGK-β Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | Q9Y6T7 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 90595 Da |
Gene ID | 1607 |
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Other Names | DGKB; DAGK2; KIAA0718; Diacylglycerol kinase beta; DAG kinase beta; 90 kDa diacylglycerol kinase; Diglyceride kinase beta; DGK-beta |
Dilution | WB~~Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide. |
Storage Conditions | -20℃ |
Name | DGKB |
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Synonyms | DAGK2, KIAA0718 |
Function | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11719522). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity). |
Cellular Location | Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q6NS52}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6NS52}. Cell membrane; Peripheral membrane protein. Cytoplasm Note=Translocation to the plasma membrane is induced by phorbol esters |
Tissue Location | [Isoform 1]: Specifically expressed in brain but also detected in uterus (PubMed:11719522). In adult brain, expressed in the amygdala, caudate nucleus, and hippocampus (PubMed:11719522) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Exhibits high phosphorylation activity for long-chain diacylglycerols.
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