Eme1 Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
---|---|
Primary Accession | Q96AY2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 63252 Da |
Gene ID | 146956 |
---|---|
Other Names | EME1; MMS4; Crossover junction endonuclease EME1; MMS4 homolog; hMMS4 |
Dilution | WB~~Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications. |
Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide. |
Storage Conditions | -20℃ |
Name | EME1 |
---|---|
Synonyms | MMS4 |
Function | Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. |
Cellular Location | Nucleus, nucleolus. Note=Recruited to regions of DNA damage in S-phase cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'- flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.
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