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GPR116 Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF |
|---|---|
| Primary Accession | Q8IZF2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 149457 Da |
| Gene ID | 221395 |
|---|---|
| Other Names | GPR116; KIAA0758; Probable G-protein coupled receptor 116 |
| Dilution | WB~~Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications. IHC-P~~N/A IF~~1:50~200 |
| Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide. |
| Storage Conditions | -20℃ |
| Name | ADGRF5 (HGNC:19030) |
|---|---|
| Synonyms | GPR116, KIAA0758 |
| Function | Adhesion G protein-coupled receptor (PubMed:28570277). In alveolar type II (ATII or AT2) cells, required for normal lung surfactant homeostasis (PubMed:28570277). Modulation of both surfactant secretion and uptake by ATII cells is mediated by the downstream activation of GNAQ/GNA11 proteins and may be a consequence of increased cortical F-actin assembly induced by ADGRF5 activation (PubMed:28570277). In the kidney, may play a role in the regulation of acid excretion into the primary urine, possibly by regulating the surface expression of V-ATPase proton pump (By similarity). As a receptor for soluble FNDC4 (sFNDC4), required for proper systemic glucose tolerance, specifically sensitizing white adipose tissue to insulin. Also plays a role in sFNDC4-induced decrease of local inflammation in white adipose tissue (PubMed:34016966). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in lung endothelial cells and in alveolar type II (ATII) cells (at protein level) (PubMed:23684610, PubMed:28570277). Expressed high levels in subcutaneous adipose tissue in lean individuals and at lower levels in visceral fat. Expression levels in subcutaneous adipose tissue drastically drop in obese individuals (PubMed:34016966). |
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function.
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$ 385.00
Cat# AP70143
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