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STK38 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q15208 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 54190 Da |
| Antigen Region | 410-439 aa |
| Gene ID | 11329 |
|---|---|
| Other Names | Serine/threonine-protein kinase 38, NDR1 protein kinase, Nuclear Dbf2-related kinase 1, STK38 {ECO:0000312|EMBL:AAH120851} |
| Target/Specificity | This STK38 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 410-439 amino acids from the C-terminal region of human STK38. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | STK38 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STK38 {ECO:0000312|EMBL:AAH12085.1} |
|---|---|
| Function | Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2. |
| Cellular Location | Nucleus. Cytoplasm. |
| Tissue Location | Ubiquitously expressed with highest levels observed in peripheral blood leukocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Stk38,also known as NUCLEAR DBF2-RELATED PROTEIN, contains 1 protein kinase domain that interacts with mob1 and mob2.The homodimeric s100b binds to two molecules of stk38. It is ubiquitously expressed with highest levels observed in peripheral blood leukocytes. Stk38 activated by binding of s100b which releases autoinhibitory n-lobe interactions, enabling atp to bind and the autophosphorylation of ser-281. thr-444 then undergoes calcium- dependent phosphorylation by an upstream kinase. Interactions between phosphorylated thr-444 and the n-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of mob1/mobkl1a and mob2/hcca2 to the n-terminal of stk38.
References
Devroe, E., et al., J. Biol. Chem. 279(23):24444-24451 (2004).
Tamaskovic, R., et al., J. Biol. Chem. 278(9):6710-6718 (2003).
Tripodis, N., et al., Genome Res. 8(6):631-643 (1998).
Millward, T., et al., Proc. Natl. Acad. Sci. U.S.A. 92(11):5022-5026 (1995).
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