ACVR2A Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | P27037 |
Other Accession | P38444, P27038, Q90669, Q28043, Q28560 |
Reactivity | Human, Mouse |
Predicted | Bovine, Chicken, Rat, Sheep |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 57848 Da |
Antigen Region | 2-29 aa |
Gene ID | 92 |
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Other Names | Activin receptor type-2A, Activin receptor type IIA, ACTR-IIA, ACTRIIA, ACVR2A, ACVR2 |
Target/Specificity | This ACVR2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-29 amino acids from the N-terminal region of human ACVR2A. |
Dilution | WB~~1:2000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ACVR2A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ACVR2A (HGNC:173) |
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Synonyms | ACVR2 |
Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A (PubMed:17911401). Mediates induction of adipogenesis by GDF6 (By similarity). |
Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P27038}; Single-pass type I membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
ACVR2A is an activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
References
Jung, B., et al., Gastroenterology 126(3):654-659 (2004).
Martins da Silva, S.J., et al., Dev. Biol. 266(2):334-345 (2004).
Olaru, A., et al., Lab. Invest. 83(12):1867-1871 (2003).
Casagrandi, D., et al., Mol. Hum. Reprod. 9(4):199-203 (2003).
Greenwald, J., et al., Mol. Cell 11(3):605-617 (2003).
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