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NHE-6 Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q92581 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 77917 Da |
| Gene ID | 10479 |
|---|---|
| Other Names | SLC9A6; KIAA0267; NHE6; Sodium/hydrogen exchanger 6; Na(+)/H(+) exchanger 6; NHE-6; Solute carrier family 9 member 6 |
| Dilution | WB~~Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications. |
| Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide. |
| Storage Conditions | -20℃ |
| Name | SLC9A6 (HGNC:11079) |
|---|---|
| Synonyms | KIAA0267, NHE6 |
| Function | Endosomal Na(+), K(+)/H(+) antiporter (PubMed:15522866, PubMed:31676550, PubMed:32277048, PubMed:28635961). Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+). By facilitating proton efflux, SLC9A6 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Responsible for alkalizing and maintaining the endosomal pH, and consequently in, e.g., endosome maturation and trafficking of recycling endosomal cargo (PubMed:15522866, PubMed:31676550, PubMed:32277048, PubMed:28635961). Plays a critical role during neurodevelopment by regulating synaptic development and plasticity (By similarity). Implicated in the maintenance of cell polarity in a manner that is dependent on its ability to modulate intravesicular pH (PubMed:20130086). Regulates intracelular pH in some specialized cells, osteoclasts and stereocilia where this transporter localizes to the plasma membrane (By similarity). |
| Cellular Location | Endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Present predominantly in the recycling compartments including early and recycling endosomes, but undergoes plasma membrane localization during vesicular recycling, which is enhanced upon certain stimuli, such as hypoxia (PubMed:28635961, PubMed:11940519, PubMed:30296617). Has a major plasmalemmal distribution in a few specialized cells, such as in vestibular hair bundles and osteoblasts (By similarity) {ECO:0000250|UniProtKB:A1L3P4, ECO:0000269|PubMed:11940519, ECO:0000269|PubMed:28635961, ECO:0000269|PubMed:30296617} |
| Tissue Location | Ubiquitous. High expression in brain, skeletal muscle, and heart, but is also detected at lower levels in most other tissues. |
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis.
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$ 350.00
Cat# AP71300
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