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Guanylyl Cyclase alpha 1 (GUCY1A3) Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q02108 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 77452 Da |
| Antigen Region | 269-300 aa |
| Gene ID | 2982 |
|---|---|
| Other Names | Guanylate cyclase soluble subunit alpha-3, GCS-alpha-3, GCS-alpha-1, Soluble guanylate cyclase large subunit, GUCY1A3, GUC1A3, GUCSA3, GUCY1A1 |
| Target/Specificity | This Guanylyl Cyclase alpha 1 (GUCY1A3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 269-300 amino acids from the N-terminal region of human Guanylyl Cyclase alpha 1 (GUCY1A3). |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Guanylyl Cyclase alpha 1 (GUCY1A3) Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GUCY1A1 (HGNC:4685) |
|---|---|
| Cellular Location | Cytoplasm. |
| Tissue Location | Detected in brain cortex and lung (at protein level). |
Provided below are standard protocols that you may find useful for product applications.
Background
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.
References
Saino, M., et al., Oncol. Rep. 12(1):47-52 (2004).
Zhou, Y., et al., Gene 245(2):319-328 (2000).
Papapetropoulos, A., et al., J. Cell. Physiol. 167(2):213-221 (1996).
Giuili, G., et al., Hum. Genet. 91(3):257-260 (1993).
Giuili, G., et al., FEBS Lett. 304(1):83-88 (1992).
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