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STK19 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P49842 |
| Other Accession | Q5ST75 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 28465 Da |
| Antigen Region | 278-308 aa |
| Gene ID | 8859 |
|---|---|
| Other Names | Serine/threonine-protein kinase 19, Protein G11, Protein RP1, STK19, G11, RP1 |
| Target/Specificity | This STK19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 278-308 amino acids from the C-terminal region of human STK19. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | STK19 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | WHR1 (HGNC:11398) |
|---|---|
| Function | DNA-binding protein which is required for efficient transcription-coupled nucleotide excision repair (TC-NER) (PubMed:38252411, PubMed:38890355, PubMed:39353615, PubMed:39547223, PubMed:39547228, PubMed:39547229). Acts as part of a TC-NER complex which assembles and interacts with RNA polymerase II (RNAPII) when it stalls at DNA lesions (PubMed:39547223, PubMed:39547228, PubMed:39547229). TC-NER complex subunit UVSSA binds to the GTF2H1/p62 subunit of the TFIIH transcription factor complex, tethering TFIIH to the TC-NER complex (PubMed:39547228). WHR1/STK19 then interacts with the XPD helicase subunit of TFIIH which guides TFIIH to DNA downstream of the stalled RNAPII, ensuring DNA repair (PubMed:39353615, PubMed:39547228, PubMed:39547229). Directly interacts with RNAPII and also binds to downstream DNA (PubMed:39547229). Promotes the timely removal of DNA damage-stalled RNAPII, allowing downstream NER factors to access DNA lesions (PubMed:39547228, PubMed:39547229). Required for monoubiquitination of UVSSA (PubMed:39353615). Regulates repositioning and stabilization of UVSSA within the TC-NER complex (PubMed:39547223). Stimulates ubiquitination of RNAPII complex member RBP1 (PubMed:39547223). Also binds to RNA and regulates the expression levels of many mRNAs (PubMed:38252411, PubMed:38890355). |
| Cellular Location | [Isoform 4]: Nucleus [Isoform 1]: Nucleus. Cytoplasm |
| Tissue Location | Monocytes, hepatocytes, epithelial cells, T- and B- lymphocytes. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SSTK19 is a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation.
References
Gomez-Escobar, N., et al., J. Biol. Chem. 273(47):30954-30960 (1998).
Yang, Z., et al., Genomics 53(3):338-347 (1998).
Ulgiati, D., et al., Immunogenetics 43(4):250-252 (1996).
Sargent, C.A., et al., Hum. Mol. Genet. 3(3):481-488 (1994).
Shen, L., et al., J. Biol. Chem. 269(11):8466-8476 (1994).
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