PRDM12 Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IF |
---|---|
Primary Accession | Q9H4Q4 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 40403 Da |
Gene ID | 59335 |
---|---|
Other Names | PRDM12; PFM9; PR domain zinc finger protein 12; PR domain-containing protein 12 |
Dilution | WB~~Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications. IF~~1:50~200 |
Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide. |
Storage Conditions | -20℃ |
Name | PRDM12 |
---|---|
Synonyms | PFM9 |
Function | Transcriptional regulator necessary for the development of nociceptive neurons, playing a key role in determining the nociceptive lineage from neural crest cell progenitors. Initiates neurogenesis and activates downstream pro-neuronal transcription factors, such as NEUROD1, BRN3A, and ISL1, specifically within nociceptive neurons, while repressing non-nociceptor cell fates. Essential for the proper function of nociceptors in adults, influencing both their excitability and their gene expression, thereby impacting how these neurons respond to various pain stimuli. |
Cellular Location | Nucleus. |
Tissue Location | Not found in adult tissues except in dorsal root ganglia. |

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Provided below are standard protocols that you may find useful for product applications.
Background
Involved in the positive regulation of histone H3-K9 dimethylation.

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