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RBM16 Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9UPN6 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 140519 Da |
| Gene ID | 22828 |
|---|---|
| Other Names | SCAF8; CCAP7; KIAA1116; RBM16; Protein SCAF8; CDC5L complex-associated protein 7; RNA-binding motif protein 16; SR-related and CTD-associated factor 8 |
| Dilution | WB~~Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications. |
| Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide. |
| Storage Conditions | -20℃ |
| Name | SCAF8 {ECO:0000303|PubMed:9528809, ECO:0000312|HGNC:HGNC:20959} |
|---|---|
| Function | Anti-terminator protein required to prevent early mRNA termination during transcription (PubMed:31104839). Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins (PubMed:31104839). Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation (PubMed:31104839). Independently of SCAF4, also acts as a positive regulator of transcript elongation (PubMed:31104839). |
| Cellular Location | Nucleus. Nucleus matrix. Note=Detected in granular nuclear foci which correspond to sites of active transcription |
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
May play a role in mRNA processing.
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$ 350.00
Cat# AP72209
Ordering Information
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