INS (Insulin) Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, IF, WB, E |
---|---|
Primary Accession | P01308 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 11981 Da |
Antigen Region | 35-64 aa |
Gene ID | 3630 |
---|---|
Other Names | Insulin, Insulin B chain, Insulin A chain, INS |
Target/Specificity | This INS (Insulin) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-64 amino acids from the Central region of human INS (Insulin). |
Dilution | IF~~1:10~50 WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | INS (Insulin) Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | INS |
---|---|
Function | Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. |
Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake.
References
Nordquist,L., Diabetes Metab. Res. Rev. 24 (2), 165-168 (2008) Nordquist,L., (er) Am. J. Physiol. Regul. Integr. Comp. Physiol. (2007) In press Naya,T., Angiology 58 (6), 677-684 (2007)
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