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BTBD1 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - BTBD1 Antibody (Center) AP7323c
    Western blot analysis of BTBD1 antibody (Center) (Cat.#AP7323c) in 293 cell line lysates (35ug/lane). BTBD1 (arrow) was detected using the purified Pab.
    detail
  • WB - BTBD1 Antibody (Center) AP7323c
    Western blot analysis of BTBD1 antibody (Center) (Cat.#AP7323c) in mouse cerebellum tissue lysates (35ug/lane). BTBD1 (arrow) was detected using the purified Pab.
    detail
  • FC - BTBD1 Antibody (Center) AP7323c
    BTBD1 Antibody (Center) (Cat. #AP7323c) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, WB, E
Primary Accession Q9H0C5
Other Accession P58544
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 52771 Da
Antigen Region 295-322 aa
Additional Information
Gene ID 53339
Other Names BTB/POZ domain-containing protein 1, Hepatitis C virus NS5A-transactivated protein 8, HCV NS5A-transactivated protein 8, BTBD1, C15orf1, NS5ATP8
Target/Specificity This BTBD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 295-322 amino acids from the Central region of human BTBD1.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBTBD1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BTBD1
Synonyms C15orf1, NS5ATP8
Function Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism (By similarity). May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis (By similarity).
Cellular Location Cytoplasm. Note=Localizes to punctate or elongated cytoplasmic bodies.
Tissue Location Ubiquitous; highest levels in testes, heart and skeletal muscle.
Research Areas
Citations (0)
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Background

BTBD1 binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies.

References

Pisani,D.F., Cabane,C. Cell Death Differ. 11 (11), 1157-1165 (2004)
Xu,L., Yang,L. Exp. Cell Res. 288 (1), 84-93 (2003)
Xu,L., Yang,L. BMC Genomics 3 (1), 1 (2002)

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$ 182.50
$ 70.00
Cat# AP7323c
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