CPA4 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9UI42 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 47351 Da |
Antigen Region | 305-336 aa |
Gene ID | 51200 |
---|---|
Other Names | Carboxypeptidase A4, 3417-, Carboxypeptidase A3, CPA4, CPA3 |
Target/Specificity | This CPA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-336 amino acids from the C-terminal region of human CPA4. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CPA4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CPA4 |
---|---|
Synonyms | CPA3 |
Function | Metalloprotease that could be involved in the histone hyperacetylation pathway (PubMed:10383164). Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val (PubMed:20385563). |
Cellular Location | Secreted. |
Tissue Location | Fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver and lung. Except for fetal brain that shows no imprinting, expression was found preferentially from the maternal allele |
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Provided below are standard protocols that you may find useful for product applications.
Background
CPA4 is a member of the carboxypeptidase A/B subfamily. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This protein could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate protein for prostate cancer aggressiveness.
References
Ross,P.L., Cheng,I. BMC Cancer 9, 69 (2009)
Bentley,L., Nakabayashi,K. J. Med. Genet. 40 (4), 249-256 (2003)
Kayashima,T., Yamasaki,K. Hum. Genet. 112 (3), 220-226 (2003)
Hayashida,S., Yamasaki,K. Genomics 66 (2), 221-225 (2000)
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