DRA Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | P40879 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 84505 Da |
Gene ID | 1811 |
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Other Names | SLC26A3; DRA; Chloride anion exchanger; Down-regulated in adenoma; Protein DRA; Solute carrier family 26 member 3 |
Dilution | WB~~Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications. |
Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide. |
Storage Conditions | -20℃ |
Name | SLC26A3 |
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Synonyms | DRA |
Function | Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia (PubMed:16606687, PubMed:19321737, PubMed:22159084, PubMed:22627094). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity). |
Cellular Location | Apical cell membrane; Multi-pass membrane protein. Membrane {ECO:0000250|UniProtKB:Q9WVC8}; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Localized in sperm membranes Midpiece of sperm tail. Colocalizes with CFTR at the midpiece of sperm tail (By similarity). {ECO:0000250|UniProtKB:Q9WVC8} |
Tissue Location | Expressed in the colon. Expression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon |
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Provided below are standard protocols that you may find useful for product applications.
Background
Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
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