IL-19 Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P |
---|---|
Primary Accession | Q9UHD0 |
Reactivity | Human, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 20452 Da |
Gene ID | 29949 |
---|---|
Other Names | Interleukin-19 (IL-19) (Melanoma differentiation-associated protein-like protein) (NG.1) |
Dilution | WB~~WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000 |
Format | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide. |
Storage Conditions | -20℃ |
Name | IL19 |
---|---|
Synonyms | ZMDA1 |
Function | Cytokine that functions as an anti-inflammatory and proangiogenic factor (PubMed:34932373). Polarizes adaptive immunity to an anti-inflammatory phenotype through induction of T-helper 2 responses by both down-regulation of IFN-gamma and up-regulation of IL4 and IL13 (PubMed:16365913). Produced by osteocytes, stimulates granulopoiesis and neutrophil formation (By similarity). Exerts its biological effect through a receptor complex consisting of a heterodimer of IL20RA and IL20RB (PubMed:12351624). In turn, activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, and importantly, STAT3 (PubMed:11564763). |
Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity).
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