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Mouse Hmx3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P42581 |
| Reactivity | Mouse |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 37859 Da |
| Antigen Region | 193-224 aa |
| Gene ID | 15373 |
|---|---|
| Other Names | Homeobox protein HMX3, Homeobox protein H6 family member 3, Homeobox protein Nkx-51, Hmx3, Nkx-51, Nkx5-1 |
| Target/Specificity | This Mouse Hmx3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 193-224 amino acids from the C-terminal region of mouse Hmx3. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Hmx3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Hmx3 |
|---|---|
| Synonyms | Nkx-5.1, Nkx5-1 |
| Function | Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS. |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed in the developing CNS, including a specific expression in vestibular structures throughout inner ear development. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Hmx3 is a transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. This protein binds to the 5'-CAAGTG-3' core sequence. It controls semicircular canal formation in the inner ear and is also required for hypothalamic/pituitary axis of the CNS.
References
Mennerich D., Hoffmann S.,Biol. Chem. 380:1041-1048(1999)
Rinkwitz-Brandt S., Justus M.,Mech. Dev. 52:371-381(1995)
Rinkwitz-Brandt S., Arnold H.H., Bober E.Hear. Res. 99:129-138(1996)
Amendt B.A., Sutherland L.B.,J. Biol. Chem. 274:11635-11642(1999)
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