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ARSB Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | P15848 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 59687 Da |
| Antigen Region | 464-493 aa |
| Gene ID | 411 |
|---|---|
| Other Names | Arylsulfatase B, ASB, N-acetylgalactosamine-4-sulfatase, G4S, ARSB |
| Target/Specificity | This ARSB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 464-493 amino acids from the C-terminal region of human ARSB. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ARSB Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ARSB |
|---|---|
| Function | Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed:19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed:19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). |
| Cellular Location | Lysosome {ECO:0000250|UniProtKB:P50429}. Cell surface {ECO:0000250|UniProtKB:P50429} |
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Provided below are standard protocols that you may find useful for product applications.
Background
ARSB belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targetted to the lysozyme. Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B.
References
Peters C., Schmidt B.J. Biol. Chem. 265:3374-3381(1990)
Modaressi S., Rupp K.Biol. Chem. Hoppe-Seyler 374:327-335(1993)
Kobayashi T., Honke K.Biochim. Biophys. Acta 1159:243-247(1992)
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