IGFALS Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
---|---|
Primary Accession | P35858 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 66035 Da |
Antigen Region | 308-335 aa |
Gene ID | 3483 |
---|---|
Other Names | Insulin-like growth factor-binding protein complex acid labile subunit, ALS, IGFALS, ALS |
Target/Specificity | This IGFALS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-335 amino acids from the Central region of human IGFALS. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | IGFALS Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | IGFALS |
---|---|
Synonyms | ALS |
Function | Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion. |
Cellular Location | Secreted, extracellular space. |
Tissue Location | Plasma. |
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Provided below are standard protocols that you may find useful for product applications.
Background
IGFALS is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this protein are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty.
References
Leong S.R., Baxter R.C.Mol. Endocrinol. 6:870-876(1992)
Suwanichkul A.Endocrinology 141:833-838(2000)
Liu T., Qian W.-J.J. Proteome Res. 4:2070-2080(2005)
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