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VCAM1 Rabbit mAb
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- BACKGROUND
Application 
| WB, IP |
|---|---|
| Primary Accession | P29533 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Calculated MW | 81317 Da |
| Other Names | Vcam1 |
|---|---|
| Dilution | WB~~1/500-1/1000 IP~~N/A |
| Format | Liquid |
| Name | Vcam1 |
|---|---|
| Synonyms | Vcam-1 |
| Function | Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Also serves as a quality- control checkpoint for entry into bone marrow by providing a 'don't- eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation. |
| Cellular Location | [Vascular cell adhesion protein 1]: Cell membrane {ECO:0000250|UniProtKB:P19320}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P19320} |
| Tissue Location | Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Expressed in the bone marrow |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 385.00
Cat# AP74998
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