ALAS2 Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IP |
---|---|
Primary Accession | P22557 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Monoclonal Antibody |
Calculated MW | 64633 Da |
Gene ID | 212 |
---|---|
Other Names | ALAS2 |
Dilution | WB~~1/500-1/1000 IP~~N/A |
Format | Liquid |
Name | ALAS2 {ECO:0000303|PubMed:34492704, ECO:0000312|HGNC:HGNC:397} |
---|---|
Function | Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products (PubMed:14643893, PubMed:21252495, PubMed:21309041, PubMed:21653323, PubMed:32499479, PubMed:34492704). Contributes significantly to heme formation during erythropoiesis (PubMed:2050125). |
Cellular Location | Mitochondrion inner membrane; Peripheral membrane protein. Note=Localizes to the matrix side of the mitochondrion inner membrane. |
Tissue Location | [Isoform 1]: Erythroid-specific. [Isoform 3]: Erythroid-specific. |

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