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BACE1 Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IP |
|---|---|
| Primary Accession | P56818 |
| Reactivity | Rat |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Calculated MW | 55748 Da |
| Gene ID | 23821 |
|---|---|
| Other Names | Bace1 |
| Dilution | WB~~1/500-1/1000 IP~~N/A |
| Format | Liquid |
| Name | Bace1 {ECO:0000312|MGI:MGI:1346542} |
|---|---|
| Synonyms | Bace |
| Function | Responsible for the proteolytic processing of the amyloid precursor protein (APP) (PubMed:29325091). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (PubMed:29325091). Cleaves CHL1 (PubMed:29325091). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P56817}; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum {ECO:0000250|UniProtKB:P56817}. Endosome. Late endosome. Early endosome. Cell surface. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P56817}. Membrane raft. Lysosome Recycling endosome. Cell projection, axon. Cell projection, dendrite. Note=Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface (By similarity). Colocalization with APP in early endosomes is due to addition of bisecting N-acetylglucosamine which blocks targeting to late endosomes and lysosomes (PubMed:25592972). Retrogradly transported from endosomal compartments to the trans-Golgi network in a phosphorylation- and GGA1- dependent manner (By similarity) {ECO:0000250|UniProtKB:P56817, ECO:0000269|PubMed:25592972} |
| Tissue Location | Expressed in the brain, specifically in neurons and astrocytes (at protein level). |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 385.00
Cat# AP75137
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