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CLIC4 Rabbit mAb
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- CITATIONS
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- BACKGROUND
Application 
| WB, IHC-P, IHC-F, IP, ICC |
|---|---|
| Primary Accession | Q9Y696 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Calculated MW | 28772 Da |
| Gene ID | 25932 |
|---|---|
| Other Names | CLIC4 |
| Dilution | WB~~1/500-1/1000 IHC-P~~N/A IHC-F~~N/A IP~~N/A ICC~~N/A |
| Format | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Name | CLIC4 {ECO:0000303|PubMed:12163372, ECO:0000312|HGNC:HGNC:13518} |
|---|---|
| Function | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions (By similarity) (PubMed:16176272). Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3. |
| Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane; Single-pass membrane protein. Nucleus. Cell membrane; Single-pass membrane protein. Mitochondrion {ECO:0000250|UniProtKB:Q9Z0W7}. Cell junction. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z0W7}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9Z0W7}. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles. Might not be present in the nucleus of cardiac cells. {ECO:0000250|UniProtKB:Q9Z0W7, ECO:0000269|PubMed:14569596} |
| Tissue Location | Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 385.00
Cat# AP75271
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