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DNAJB6 Rabbit mAb
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- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | O75190 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Calculated MW | 36087 Da |
| Gene ID | 10049 |
|---|---|
| Other Names | DNAJB6 |
| Dilution | WB~~1/500-1/1000 IHC-P~~N/A |
| Format | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA. |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Name | DNAJB6 |
|---|---|
| Synonyms | HSJ2, MRJ, MSJ1 |
| Function | Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co- chaperone of HSP70 (PubMed:10954706, PubMed:28233300). Plays an indispensable role in the organization of KRT8/KRT18 filaments (PubMed:10954706). Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin (PubMed:11896048, PubMed:22366786). Suppresses aggregation and toxicity of polyglutamine- containing, aggregation-prone proteins (PubMed:20159555, PubMed:22366786). Also reduces cellular toxicity and caspase-3 activity (PubMed:11896048). |
| Cellular Location | Cytoplasm, perinuclear region. Nucleus Cytoplasm, myofibril, sarcomere, Z line |
| Tissue Location | Widely expressed. Highest levels in testis and brain, and lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver and leukocytes. In testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids. In brain, expressed at a higher level in hippocampus and thalamus and a lower level in amygdala, substantia nigra, corpus callosum and caudate nucleus |
Research Areas
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Application Protocols
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$ 385.00
Cat# AP75366
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