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AK2 Rabbit mAb

     
  • WB - AK2 Rabbit mAb AP76382
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  • IHC - AK2 Rabbit mAb AP76382
    detail
  • IF - AK2 Rabbit mAb AP76382
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IHC-F, IP, ICC
Primary Accession P54819
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal Antibody
Calculated MW 26478 Da
Additional Information
Gene ID 204
Other Names AK2
Dilution WB~~1/500-1/1000
IHC~~1/50-1/100
IF~~1/50-1/200
Format Liquid
Protein Information
Name AK2 {ECO:0000255|HAMAP-Rule:MF_03168}
Synonyms ADK2
Function Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
Cellular Location Mitochondrion intermembrane space {ECO:0000255|HAMAP-Rule:MF_03168}
Tissue Location Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level)
Research Areas
Citations (0)
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$ 385.00
Cat# AP76382
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