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FKBP6 Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | O75344 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Monoclonal Antibody |
| Calculated MW | 37214 Da |
| Gene ID | 8468 |
|---|---|
| Other Names | FKBP6 |
| Dilution | WB~~1/500-1/1000 IHC-P~~N/A |
| Format | Liquid |
| Name | FKBP6 |
|---|---|
| Synonyms | FKBP36 |
| Function | Has an essential role in spermatogenesis (PubMed:36150389). It is required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). Acts as a co- chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis (By similarity). May be required together with HSP90 in removal of 16 nucleotide ping- pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity). |
| Cellular Location | Cytoplasm. Nucleus. Note=In spermatocytes, it colocalizes with PIWIL1 in large cytoplasmic granules (PubMed:36150389). Does not localize to the synaptonemal complex (PubMed:36150389) |
| Tissue Location | Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney |
Research Areas
Citations (0)
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Application Protocols
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$ 385.00
Cat# AP76501
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