MYH9 Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IHC-P, IP |
---|---|
Primary Accession | P35579 |
Reactivity | Human, Rat |
Host | Rabbit |
Clonality | Monoclonal Antibody |
Calculated MW | 226532 Da |
Gene ID | 4627 |
---|---|
Other Names | MYH9 |
Dilution | WB~~1/500-1/1000 IHC~~1/50-1/100 |
Format | Liquid |
Name | MYH9 |
---|---|
Function | Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). |
Cellular Location | Cytoplasm, cytoskeleton. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q8VDD5}. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000250|UniProtKB:Q8VDD5}. Cell membrane Note=Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells (PubMed:20052411). In retinal pigment epithelial cells, predominantly localized to stress fiber-like structures with some localization to cytoplasmic puncta (PubMed:27331610). |
Tissue Location | In the kidney, expressed in the glomeruli. Also expressed in leukocytes. |

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