|Application ||FC, IHC-P, WB, E|
|Calculated MW||14296 Da|
|Antigen Region||10-39 aa|
|Other Names||Urotensin-2, Urotensin II, U-II, UII, UTS2|
|Target/Specificity||This UTS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-39 amino acids from the N-terminal region of human UTS2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UTS2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Highly potent vasoconstrictor.|
|Tissue Location||Brain specific.|
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Provided below are standard protocols that you may find useful for product applications.
UTS2 is a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this protein is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide.
Brailoiu,E., Peptides 29 (5), 721-726 (2008)
Cirillo,P., J. Thromb. Haemost. 6 (5), 726-736 (2008)
Zoccali,C.Hypertension 51 (2), 326-333 (2008)
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