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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CYP26B1 Antibody (C-term)   

CYP26B1 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CYP26B1 Antibody (C-term) AP7994b
    Western blot analysis of anti-CYP26B1 Antibody (C-term) (Cat.#AP7994b) in 293 cell line lysates (35ug/lane). CYP26B1(arrow) was detected using the purified Pab.
  • WB - CYP26B1 Antibody (C-term) AP7994b
    Western blot analysis of CYP26B1 (arrow) using rabbit polyclonal CYP26B1 Antibody (C-term) (Cat. #AP7994b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CYP26B1 gene.
  • IHC-P - CYP26B1 Antibody (C-term) AP7994b
    Formalin-fixed and paraffin-embedded human brain tissue reacted with CYP26B1 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NR63
Other Accession G3V7X8, Q811W2
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 57513 Da
Antigen Region 398-430 aa
Additional Information
Gene ID 56603
Other Names Cytochrome P450 26B1, 114--, Cytochrome P450 26A2, Cytochrome P450 retinoic acid-inactivating 2, Cytochrome P450RAI-2, Retinoic acid-metabolizing cytochrome, CYP26B1, CYP26A2, P450RAI2
Target/Specificity This CYP26B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 398-430 amino acids from the C-terminal region of human CYP26B1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCYP26B1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CYP26B1
Synonyms CYP26A2, P450RAI2
Function Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation (PubMed:10823918, PubMed:22020119). Involved in the specific inactivation of all-trans- retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA (PubMed:10823918, PubMed:22020119). Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA (PubMed:10823918). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4 (PubMed:10823918, PubMed:22020119). Essential for postnatal survival (By similarity). Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis (By similarity). Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry (By similarity). Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints (PubMed:22019272).
Cellular Location Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O43174}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43174}. Microsome membrane {ECO:0000250|UniProtKB:O43174}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43174}
Tissue Location Highly expressed in brain, particularly in the cerebellum and pons.
Research Areas
Citations (0)

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CYP26B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene is involved in the specific inactivation of all-trans-retinoic acid to hydroxylated forms, such as 4-oxo-, 4-OH-, and 18-OH-all-trans-retinoic acid.


Bowles,J., Science 312 (5773), 596-600 (2006)
Nelson,D.R., Pharmacogenetics 14 (1), 1-18 (2004)

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Cat# AP7994b
Availability: Back Order
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