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TLK1 Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q9UKI8 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 86700 Da |
| Antigen Region | 720-750 aa |
| Gene ID | 9874 |
|---|---|
| Other Names | Serine/threonine-protein kinase tousled-like 1, PKU-beta, Tousled-like kinase 1, TLK1, KIAA0137 |
| Target/Specificity | This TLK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 720-750 amino acids from the C-terminal region of human TLK1. |
| Dilution | IHC-P~~1:50~100 WB~~1:8000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TLK1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TLK1 |
|---|---|
| Synonyms | KIAA0137 |
| Function | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. |
| Cellular Location | Nucleus |
| Tissue Location | Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined. |
Provided below are standard protocols that you may find useful for product applications.
Background
The Tousled-like kinases, first described in Arabadopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM]
References
Krause, D.R., et al., Oncogene 22(38):5927-5937 (2003).
Cabaniols, J.P., et al., Mol. Biol. Cell 10(12):4033-4041 (1999).
Sillje, H.H., et al., EMBO J. 18(20):5691-5702 (1999).
Yamakawa, A., et al., Gene 202 (1-2), 193-201 (1997).
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