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PTP gamma Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P23470 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 162003 Da |
| Antigen Region | 751-782 aa |
| Gene ID | 5793 |
|---|---|
| Other Names | Receptor-type tyrosine-protein phosphatase gamma, Protein-tyrosine phosphatase gamma, R-PTP-gamma, PTPRG, PTPG |
| Target/Specificity | This PTP gamma antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 751-782 amino acids from the Central region of human PTP gamma. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PTP gamma Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PTPRG |
|---|---|
| Synonyms | PTPG |
| Function | Possesses tyrosine phosphatase activity. |
| Cellular Location | Membrane; Single-pass type I membrane protein |
| Tissue Location | Found in a variety of tissues. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
PTPgamma is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. The gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.
References
Liu, S., et al., Breast Cancer Res. Treat. 71(1):21-35 (2002).
Kastury, K., et al., Genomics 32(2):225-235 (1996).
Barnea, G., et al., Mol. Cell. Biol. 13(3):1497-1506 (1993).
LaForgia, S., et al., Proc. Natl. Acad. Sci. U.S.A. 88(11):5036-5040 (1991).
Krueger, N.X., et al., EMBO J. 9(10):3241-3252 (1990).
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