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DUSP4 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - DUSP4 Antibody (C-term) AP8447B
    Western blot analysis of anti-DUSP4 Pab (Cat. #AP8447b) in mouse brain tissue lysate (35ug/lane). DUSP4(arrow) was detected using the purified Pab.
    detail
  • WB - DUSP4 Antibody (C-term) AP8447B
    Western blot analysis of anti-DUSP4 Antibody (C-term) (Cat.#AP8447b) in HepG2 cell line lysates (35ug/lane). DUSP4 (arrow) was detected using the purified Pab.
    detail
  • IHC-P - DUSP4 Antibody (C-term) AP8447B
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession Q13115
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 42953 Da
Antigen Region 331-361 aa
Additional Information
Gene ID 1846
Other Names Dual specificity protein phosphatase 4, Dual specificity protein phosphatase hVH2, Mitogen-activated protein kinase phosphatase 2, MAP kinase phosphatase 2, MKP-2, DUSP4, MKP2, VH2
Target/Specificity This DUSP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 331-361 amino acids from the C-terminal region of human DUSP4.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDUSP4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DUSP4
Synonyms MKP2, VH2
Function Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
Cellular Location Nucleus.
Research Areas
Citations (0)
citation

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Background

DUSP4 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP4 inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus.

References

Chen, P., et al., J. Biol. Chem. 276(31):29440-29449 (2001).
Smith, A., et al., Genomics 42(3):524-527 (1997).
Chu, Y., et al., J. Biol. Chem. 271(11):6497-6501 (1996).
King, A.G., et al., Oncogene 11(12):2553-2563 (1995).
Guan, K.L., et al., J. Biol. Chem. 270(13):7197-7203 (1995).

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$ 365.00
$ 140.00
Cat# AP8447B
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