|Application ||IHC-P, WB, E|
|Other Accession||Q91Z46, NP_001938, Q63340|
|Calculated MW||44957 Da|
|Antigen Region||96-127 aa|
|Other Names||Dual specificity protein phosphatase 7, Dual specificity protein phosphatase PYST2, DUSP7, PYST2|
|Target/Specificity||This DUSP7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-127 amino acids from the N-terminal region of human DUSP7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DUSP7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dual specificity protein phosphatase (PubMed:9788880). Shows high activity towards MAPK1/ERK2 (PubMed:9788880). Also has lower activity towards MAPK14 and MAPK8 (PubMed:9788880). In arrested oocytes, plays a role in meiotic resumption (By similarity). Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (By similarity). May also inactivate PRKCA and/or PRKCG (By similarity). Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex (By similarity).|
|Tissue Location||Strongly expressed in liver (PubMed:8670865). Expressed at significantly higher levels in malignant hematopoietic cells than in corresponding non-malignant cells (PubMed:14576828)|
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Provided below are standard protocols that you may find useful for product applications.
DUSP7 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.
Immunol. Lett. 92 (1-2), 149-156 (2004)
Oncogene 22 (48), 7649-7660 (2003)
Meth. Enzymol. 366, 103-113 (2003)
J. Cell. Sci. 111 (PT 22), 3389-3399 (1998)
EMBO J. 15 (14), 3621-3632 (1996)
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