|Application ||IHC-P, WB, E|
|Calculated MW||22149 Da|
|Antigen Region||1-30 aa|
|Other Names||Dual specificity protein phosphatase 13 isoform B, DUSP13B, Dual specificity phosphatase SKRP4, Testis- and skeletal-muscle-specific DSP, DUSP13, DUSP13B, TMDP|
|Target/Specificity||This DUSP13-M1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DUSP13-M1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DUSP13-M1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro.|
|Tissue Location||Most abundantly expressed in the testis. Also found in the skeletal muscle. Testis-specific (at protein level)|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Dual-specificity phosphatases, a subfamily of protein-tyrosine phosphatases, play important roles in signal transduction, cell cycle progression, and tumor suppression. The cDNA encoding a novel phosphatase, PIR1, phosphatase that interacts with RNA/RNP complex 1. Sequence analysis revealed that the predicted 329-amino acid protein has homology to several dual-specificity phosphatases and contains 2 stretches of arginine-rich sequence similar to those found in some RNA-binding proteins. In vitro, recombinant protein displays protein-tyrosine phosphatase activity and binds directly to RNA.
Nakamura K., Shima H., Watanabe M., Haneji T., Kikuchi K.Biochem. J. 344:819-825(1999).
Deloukas et al. Nature 429:375-381(2004).
Strausberg et al. Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
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