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PPP3CB Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - PPP3CB Antibody (N-term) AP8464a
    Western blot analysis of anti-PPP3CB Pab (Cat. #AP8464a) in mouse kidney tissue lysate. PPP3CB(arrow) was detected using the purified Pab.
    detail
  • WB - PPP3CB Antibody (N-term) AP8464a
    Western blot analysis of anti-PPP3CB Antibody (N-term) (Cat.#AP8464a) in Jurkat cell line lysates (35ug/lane). PPP3CB(arrow) was detected using the purified Pab.
    detail
  • IHC-P - PPP3CB Antibody (N-term) AP8464a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, WB, E
Primary Accession P16298
Other Accession P20651, P48453
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 59024 Da
Antigen Region 1-30 aa
Additional Information
Gene ID 5532
Other Names Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform, CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit beta isoform, PPP3CB, CALNA2, CALNB, CNA2
Target/Specificity This PPP3CB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PPP3CB.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPPP3CB Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PPP3CB
Synonyms CALNA2, CALNB, CNA2
Function Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:19154138, PubMed:25720963, PubMed:32753672, PubMed:26794871). Dephosphorylates TFEB in response to lysosomal Ca(2+) release, resulting in TFEB nuclear translocation and stimulation of lysosomal biogenesis (PubMed:25720963, PubMed:32753672). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138). Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB (By similarity). May play a role in skeletal muscle fiber type specification (By similarity).
Cellular Location Cytoplasm.
Research Areas
Citations (0)
citation

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Background

PPP3CB is a calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

References

Katanosaka, Y., et al., J. Biol. Chem. 280(7):5764-5772 (2005).
Bell, O., et al., Mol. Endocrinol. 19(2):516-526 (2005).
Bennasser, Y., et al., Virology 303(1):174-180 (2002).
Kissinger, C.R., et al., Nature 378(6557):641-644 (1995).
Muramatsu, T., et al., Biochim. Biophys. Acta 1178(1):117-120 (1993).

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$ 365.00
$ 140.00
Cat# AP8464a
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