|Application ||FC, IHC-P, WB, E|
|Calculated MW||74977 Da|
|Antigen Region||180-207 aa|
|Other Names||Rho GTPase-activating protein 18, MacGAP, Rho-type GTPase-activating protein 18, ARHGAP18 (HGNC:21035)|
|Target/Specificity||This ARHGAP18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 180-207 amino acids from the Central region of human ARHGAP18.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ARHGAP18 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595).|
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Provided below are standard protocols that you may find useful for product applications.
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
Potkin,S.G., et.al., Mol. Psychiatry 14 (4), 416-428 (2009) Lehner,B.et.al., Genome Res. 14 (7), 1315-1323 (2004)
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