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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   IL18RAP Antibody (N-term)   

IL18RAP Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - IL18RAP Antibody (N-term) AP8797a
    Western blot analysis of IL18RAP Antibody (N-term) (Cat. #AP8797a) in K562 cell line lysates (35ug/lane). IL18RAP (arrow) was detected using the purified Pab.
  • IHC-P - IL18RAP Antibody (N-term) AP8797a
    Formalin-fixed and paraffin-embedded human lung carcinoma reacted with IL18RAP Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - IL18RAP Antibody (N-term) AP8797a
    IL18RAP Antibody (N-term)(Cat. #AP8797a) flow cytometric analysis of k562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O95256
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 68310 Da
Antigen Region 73-101 aa
Additional Information
Gene ID 8807
Other Names Interleukin-18 receptor accessory protein, IL-18 receptor accessory protein, IL-18RAcP, Accessory protein-like, AcPL, CD218 antigen-like family member B, CDw218b, IL-1R accessory protein-like, IL-1RAcPL, Interleukin-1 receptor 7, IL-1R-7, IL-1R7, Interleukin-18 receptor accessory protein-like, Interleukin-18 receptor beta, IL-18R-beta, IL-18Rbeta, CD218b, IL18RAP, IL1R7
Target/Specificity This IL18RAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73-101 amino acids from the N-terminal region of human IL18RAP.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIL18RAP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL18RAP (HGNC:5989)
Synonyms IL1R7
Function Within the IL18 receptor complex, does not mediate IL18- binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:9792649, PubMed:14528293, PubMed:25500532). May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable).
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Detected in adrenal gland, bone marrow, brain, fetal brain, fetal liver, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, prostate, salivary gland, skeletal muscle, spinal cord, testis, thymus, thyroid, trachea and uterus (PubMed:17897836) Strongly expressed in peripheral blood leukocytes and spleen and, to a lesser extent, in colon (PubMed:9792649). Specifically coexpressed with IL18R1 in T-helper 1 (Th1)cells (PubMed:10925275, PubMed:11046021, PubMed:10653850).
Research Areas
Citations (0)

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IL18RAP is required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity). Together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK.


Debets R.,, J. Immunol. 165:4950-4956(2000).

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$ 325.00
$ 109.00
Cat# AP8797a
Availability: In Stock
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