|Application ||WB, IF, FC, IHC-P, E|
|Calculated MW||69623 Da|
|Antigen Region||288-317 aa|
|Other Names||Tumor protein p73, p53-like transcription factor, p53-related protein, TP73, P73|
|Target/Specificity||This TP73 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 288-317 amino acids from the Central region of human TP73.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TP73 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.|
|Cellular Location||Nucleus. Cytoplasm. Note=Accumulates in the nucleus in response to DNA damage|
|Tissue Location||Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas Highly expressed in fetal tissue.|
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Provided below are standard protocols that you may find useful for product applications.
TP73 is tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors.
Mai,M., et.al., Genomics 51 (3), 359-363 (1998) Mai,M., et.al., Oncogene 17 (13), 1739-1741 (1998)
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