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LMX1B Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - LMX1B Antibody (Center) AP8935c
    Western blot analysis of LMX1B Antibody (Center) (Cat. #AP8935c) in mouse heart tissue lysates (35ug/lane). LMX1B (arrow) was detected using the purified Pab.
  • WB - LMX1B Antibody (Center) AP8935c
    Western blot analysis of LMX1B (arrow) using rabbit polyclonal LMX1B Antibody (Center) (Cat. #AP8935c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the LMX1B gene.
  • IHC-P - LMX1B Antibody (Center) AP8935c
    Formalin-fixed and paraffin-embedded human testis tissue reacted with LMX1B Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O60663
Other Accession Q8UVR3, O88609, P53413
Reactivity Human, Mouse
Predicted Chicken, Xenopus
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 44917 Da
Antigen Region 175-202 aa
Additional Information
Gene ID 4010
Other Names LIM homeobox transcription factor 1-beta, LIM/homeobox protein 12, LMX-12, LIM/homeobox protein LMX1B, LMX1B
Target/Specificity This LMX1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-202 amino acids from the Central region of human LMX1B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLMX1B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LMX1B
Function Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels.
Cellular Location Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
Tissue Location Expressed in most tissues. Highest levels in testis, thyroid, duodenum, skeletal muscle, and pancreatic islets
Research Areas
Citations ( 0 )


LMX1B is required for the normal development of the dopaminergic system. Loss of dopaminergic neurons is associated with one of the most prominent human neurological disorders, Parkinson's disease (PD). Dopaminergic neurons play an important role in the control of multiple brain functions including voluntary movement alongside an array of behavioral processes such as mood, reward, addiction, and stress. Lmx1b is one of several transcription factors involved in the generation of dopaminergic neurons in the brain.


Ham,J.H.,, Korean J. Intern. Med. 24 (3), 274-278 (2009)
Bergman,O.,, J Neural Transm 116 (3), 333-338 (2009)

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$ 325.00
$ 109.00
Cat# AP8935c
Availability: In Stock
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