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LMX1B Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | O60663 |
| Other Accession | Q8UVR3, O88609, P53413 |
| Reactivity | Human, Mouse |
| Predicted | Chicken, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 44917 Da |
| Antigen Region | 175-202 aa |
| Gene ID | 4010 |
|---|---|
| Other Names | LIM homeobox transcription factor 1-beta, LIM/homeobox protein 12, LMX-12, LIM/homeobox protein LMX1B, LMX1B |
| Target/Specificity | This LMX1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-202 amino acids from the Central region of human LMX1B. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | LMX1B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LMX1B |
|---|---|
| Function | Transcription factor involved in the regulation of podocyte- expressed genes (PubMed:24042019, PubMed:28059119). Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. |
| Tissue Location | Expressed in most tissues. Highest levels in testis, thyroid, duodenum, skeletal muscle, and pancreatic islets |
Provided below are standard protocols that you may find useful for product applications.
Background
LMX1B is required for the normal development of the dopaminergic system. Loss of dopaminergic neurons is associated with one of the most prominent human neurological disorders, Parkinson's disease (PD). Dopaminergic neurons play an important role in the control of multiple brain functions including voluntary movement alongside an array of behavioral processes such as mood, reward, addiction, and stress. Lmx1b is one of several transcription factors involved in the generation of dopaminergic neurons in the brain.
References
Ham,J.H., et.al., Korean J. Intern. Med. 24 (3), 274-278 (2009)
Bergman,O., et.al., J Neural Transm 116 (3), 333-338 (2009)
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