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TGOLN2 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TGOLN2 Antibody (C-term) AP8955b
    Anti-TGOLN2 Antibody (C-term) at 1:1000 dilution + MCF-7 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 51 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • FC - TGOLN2 Antibody (C-term) AP8955b
    TGOLN2 Antibody (C-term) (Cat.#AP8955b) flow cytometry analysis of MDA-MB231 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, WB, E
Primary Accession O43493
Other Accession P19814, Q62314, Q62313
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 399-427 aa
Additional Information
Other Names Trans-Golgi network integral membrane protein 2, TGN38 homolog, TGN46, TGN48, Trans-Golgi network protein TGN51, TGOLN2, TGN46, TGN51
Target/Specificity This TGOLN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 399-427 amino acids from the C-terminal region of human TGOLN2.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTGOLN2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TGOLN2 (HGNC:15450)
Synonyms TGN46, TGN51
Function May be involved in regulating membrane traffic to and from trans-Golgi network.
Cellular Location Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Note=Primarily in trans-Golgi network. Cycles between the trans-Golgi network and the cell surface returning via endosomes
Tissue Location Isoform TGN46 is widely expressed. Isoform TGN51 is more abundant in fetal lung and kidney. Isoform TGN48 is barely expressed in embryonic kidney and promyelocytic cells EMBL; AF029316; AAB96906.1; -; Genomic_DNA EMBL; AF029313; AAB96906.1; JOINED; Genomic_DNA EMBL; AF029314; AAB96906.1; JOINED; Genomic_DNA EMBL; AF029315; AAB96906.1; JOINED; Genomic_DNA EMBL; AF029316; AAB96907.1; -; Genomic_DNA EMBL; AF029313; AAB96907.1; JOINED; Genomic_DNA EMBL; AF029314; AAB96907.1; JOINED; Genomic_DNA EMBL; AF029315; AAB96907.1; JOINED; Genomic_DNA EMBL; AF029316; AAB96908.1; -; Genomic_DNA EMBL; AF029313; AAB96908.1; JOINED; Genomic_DNA EMBL; AF029314; AAB96908.1; JOINED; Genomic_DNA EMBL; AF029315; AAB96908.1; JOINED; Genomic_DNA EMBL; U62390; AAC39539.1; -; mRNA EMBL; AF027515; AAC39541.1; -; mRNA EMBL; AF027516; AAC39542.1; -; mRNA EMBL; X94333; CAA64002.1; -; mRNA EMBL; AK126465; BAC86559.1; -; mRNA EMBL; AK222829; BAD96549.1; -; mRNA EMBL; AK223063; BAD96783.1; -; mRNA EMBL; AK312479; BAG35383.1; -; mRNA EMBL; BX640868; CAE45926.1; -; mRNA EMBL; AC093162; AAY24095.1; -; Genomic_DNA EMBL; CH471053; EAW99535.1; -; Genomic_DNA EMBL; CH471053; EAW99536.1; -; Genomic_DNA EMBL; CH471053; EAW99539.1; -; Genomic_DNA EMBL; BC008461; AAH08461.1; -; mRNA EMBL; BC028219; AAH28219.1; -; mRNA CCDS; CCDS46351.1; -. [O43493-2] CCDS; CCDS56126.1; -. [O43493-3] CCDS; CCDS56127.1; -. [O43493-4] RefSeq; NP_001193769.1; NM_001206840.1 RefSeq; NP_001193770.1; NM_001206841.1 RefSeq; NP_001193773.1; NM_001206844.1. [O43493-4] RefSeq; NP_006455.2; NM_006464.3. [O43493-2] BioGRID; 115864; 459 IntAct; O43493; 445 MINT; O43493; - STRING; 9606.ENSP00000386443; - GlyGen; O43493; 13 sites, 1 O-linked glycan (4 sites) iPTMnet; O43493; - PhosphoSitePlus; O43493; - BioMuta; TGOLN2; - EPD; O43493; - jPOST; O43493; - MassIVE; O43493; - PaxDb; O43493; - PeptideAtlas; O43493; - PRIDE; O43493; - ProteomicsDB; 30219; - ProteomicsDB; 30837; - ProteomicsDB; 48977; -. [O43493-2] ProteomicsDB; 48978; -. [O43493-3] ProteomicsDB; 48979; -. [O43493-4] ProteomicsDB; 48980; -. [O43493-5] ProteomicsDB; 48981; -. [O43493-6] Antibodypedia; 2516; 316 antibodies DNASU; 10618; - Ensembl; ENST00000377386; ENSP00000366603; ENSG00000152291. [O43493-2] Ensembl; ENST00000398263; ENSP00000381312; ENSG00000152291. [O43493-4] Ensembl; ENST00000409015; ENSP00000387035; ENSG00000152291. [O43493-7] Ensembl; ENST00000444342; ENSP00000391190; ENSG00000152291. [O43493-5] GeneID; 10618; - KEGG; hsa:10618; - UCSC; uc002soz.4; human. [O43493-2] UCSC; uc021vjw.2; human CTD; 10618; - DisGeNET; 10618; - EuPathDB; HostDB:ENSG00000152291.13; - GeneCards; TGOLN2; - HGNC; HGNC:15450; TGOLN2 HPA; ENSG00000152291; Low tissue specificity MIM; 603062; gene neXtProt; NX_O43493; - OpenTargets; ENSG00000152291; - PharmGKB; PA37959; - eggNOG; ENOG502S6YU; Eukaryota GeneTree; ENSGT00530000064712; - HOGENOM; CLU_047350_0_0_1; - InParanoid; O43493; - OrthoDB; 1481309at2759; - PhylomeDB; O43493; - TreeFam; TF332514; - PathwayCommons; O43493; - Reactome; R-HSA-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Reactome; R-HSA-432722; Golgi Associated Vesicle Biogenesis Reactome; R-HSA-6811440; Retrograde transport at the Trans-Golgi-Network Reactome; R-HSA-8856825; Cargo recognition for clathrin-mediated endocytosis Reactome; R-HSA-8856828; Clathrin-mediated endocytosis Reactome; R-HSA-8957275; Post-translational protein phosphorylation BioGRID-ORCS; 10618; 4 hits in 880 CRISPR screens ChiTaRS; TGOLN2; human GeneWiki; TGOLN2; - GenomeRNAi; 10618; - Pharos; O43493; Tbio PRO; PR:O43493; - Proteomes; UP000005640; Chromosome 2 RNAct; O43493; protein Bgee; ENSG00000152291; Expressed in adult mammalian kidney and 256 other tissues Genevisible; O43493; HS GO; GO:0030665; C:clathrin-coated vesicle membrane; TAS:Reactome GO; GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome GO; GO:0005768; C:endosome; IBA:GO_Central GO; GO:0005794; C:Golgi apparatus; IDA:HPA GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0005654; C:nucleoplasm; IDA:HPA GO; GO:0005886; C:plasma membrane; TAS:Reactome GO; GO:0005802; C:trans-Golgi network; IDA:MGI GO; GO:0030140; C:trans-Golgi network transport vesicle; IBA:GO_Central GO; GO:0030133; C:transport vesicle; TAS:ProtInc GO; GO:0044267; P:cellular protein metabolic process; TAS:Reactome GO; GO:0061024; P:membrane organization; TAS:Reactome GO; GO:0043687; P:post-translational protein modification; TAS:Reactome 1: Evidence at protein level; Alternative splicing; Cell membrane; Glycoprotein; Golgi apparatus; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix SIGNAL 1..21 /evidence="ECO:0000255" CHAIN 22..437 /note="Trans-Golgi network integral membrane protein 2" /id="PRO_0000022486" TOPO_DOM 22..381 /note="Extracellular" /evidence="ECO:0000255" TRANSMEM 382..402 /note="Helical" /evidence="ECO:0000255" TOPO_DOM 403..437 /note="Cytoplasmic" /evidence="ECO:0000255" REPEAT 54..67 /note="1" REPEAT 68..81 /note="2" REPEAT 82..95 /note="3" REPEAT 96..109 /note="4" REPEAT 110..123 /note="5" REPEAT 124..137 /note="6" REPEAT 138..151 /note="7" REPEAT 152..165 /note="8" REPEAT 166..179 /note="9" REPEAT 180..193 /note="10" REPEAT 194..207 /note="11" REPEAT 208..221 /note="12" REPEAT 222..234 /note="13" REPEAT 235..249 /note="14" REGION 54..249 /note="14 X 14 AA tandem repeats" MOTIF 395..398 /note="Endocytosis signal; in isoform TGN51" MOTIF 418..421 /note="Endocytosis signal; in isoform TGN51" MOTIF 430..433 /note="Endocytosis signal; in isoform TGN46 and isoform TGN48" MOD_RES 71 /note="Phosphoserine; by FAM20C" /evidence="ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:21406692, ECO:0000244|PubMed:23186163, ECO:0000244|PubMed:24275569, ECO:0000269|PubMed:26091039" MOD_RES 221 /note="Phosphoserine; by FAM20C" /evidence="ECO:0000269|PubMed:26091039" MOD_RES 298 /note="Phosphoserine; by FAM20C" /evidence="ECO:0000244|PubMed:23186163, ECO:0000269|PubMed:26091039" MOD_RES 302 /note="Phosphothreonine; by FAM20C" /evidence="ECO:0000269|PubMed:26091039" MOD_RES 351 /note="Phosphoserine; by FAM20C" /evidence="ECO:0000244|PubMed:24275569, ECO:0000269|PubMed:26091039" CARBOHYD 39 /note="N-linked (GlcNAc...) asparagine" /evidence="ECO:0000255" CARBOHYD 82 /note="N-linked (GlcNAc...) asparagine" /evidence="ECO:0000255" CARBOHYD 96 /note="N-linked (GlcNAc...) asparagine" /evidence="ECO:0000255" CARBOHYD 152 /note="N-linked (GlcNAc...) asparagine" /evidence="ECO:0000255" CARBOHYD 180 /note="N-linked (GlcNAc...) asparagine" /evidence="ECO:0000255" CARBOHYD 208 /note="N-linked (GlcNAc...) asparagine" /evidence="ECO:0000255" CARBOHYD 222 /note="N-linked (GlcNAc...) asparagine" /evidence="ECO:0000255" CARBOHYD 373 /note="N-linked (GlcNAc...) asparagine" /evidence="ECO:0000255" CARBOHYD 377 /note="N-linked (GlcNAc...) asparagine" /evidence="ECO:0000255" VAR_SEQ 71..168 /note="Missing (in isoform 6)" /id="VSP_060318" VAR_SEQ 251..309 /note="KVVPEQPSRKDHSKPISNPSDNKELPKADTNQLADKGKLSPHAFKTESGEET DLISPPQ -> K (in isoform 4)" /id="VSP_060319" VAR_SEQ 252..309 /note="Missing (in isoform 6)" /id="VSP_060320" VAR_SEQ 437 /note="S -> VRKEEPGPWEG (in isoform 5)" /id="VSP_060321" VAR_SEQ 437 /note="S -> YVLILNVFPAPPKRSFFP (in isoform 7)" /id="VSP_060322" VAR_SEQ 437 /note="S -> IFSPPSPNRMVYSSGKR (in isoform TGN48)" /evidence="ECO:0000303|PubMed:9422759" /id="VSP_060323" VARIANT 10 /note="L -> V (in dbSNP:rs1128140)" /evidence="ECO:0000269|PubMed:9422759" /id="VAR_034724" VARIANT 86 /note="A -> G (in dbSNP:rs1044962)" /evidence="ECO:0000269|PubMed:9422759" /id="VAR_034725" VARIANT 91 /note="Q -> L (in dbSNP:rs1044963)" /evidence="ECO:0000269|PubMed:9422759" /id="VAR_034726" VARIANT 103 /note="K -> Q (in dbSNP:rs1044964)" /evidence="ECO:0000269|PubMed:9422759" /id="VAR_034727" VARIANT 105 /note="Q -> P" /evidence="ECO:0000269|PubMed:9422759" /id="VAR_034728" VARIANT 259 /note="R -> W (in dbSNP:rs4247303)" /evidence="ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:8907712, ECO:0000269|Ref.4, ECO:0000269|Ref.7" /id="VAR_034729" VARIANT 322 /note="E -> G (in dbSNP:rs1044969)" /evidence="ECO:0000269|PubMed:9422759" /id="VAR_034730" MUTAGEN 430 /note="Y->A: Loss of relocalization to the trans-Golgi." /evidence="ECO:0000269|PubMed:9422759" CONFLICT 30 /note="E -> D (in Ref. 8; AAH08461)" /evidence="ECO:0000305" CONFLICT 71 /note="S -> G (in Ref. 4; BAD96549)" /evidence="ECO:0000305" CONFLICT 74 /note="A -> P (in Ref. 4; BAD96783)" /evidence="ECO:0000305" CONFLICT 158 /note="A -> P (in Ref. 1; AAB96906/AAB96907/AAB96908/ AAC39539/AAC39541/AAC39542)" /evidence="ECO:0000305" CONFLICT 386 /note="F -> S (in Ref. 5; CAE45926)" /evidence="ECO:0000305" VARIANT O43493-3:441 /note="P -> L (in dbSNP:rs4240199)" /evidence="ECO:0000305" /id="VAR_082887" CONFLICT O43493-3:439 /note="S -> F (in Ref. 1; AAC39541/AAB96907)" CONFLICT O43493-7:453 /note="F -> L (in Ref. 1; AAB96908/AAC39542)" SEQUENCE 437 AA; 45880 MW; 6F72467FED83A1A3 CRC64; MRFVVALVLL NVAAAGAVPL LATESVKQEE AGVRPSAGNV STHPSLSQRP GGSTKSHPEP QTPKDSPSKS SAEAQTPEDT PNKSGAEAKT QKDSSNKSGA EAKTQKGSTS KSGSEAQTTK DSTSKSHPEL QTPKDSTGKS GAEAQTPEDS PNRSGAEAKT QKDSPSKSGS EAQTTKDVPN KSGADGQTPK DGSSKSGAED QTPKDVPNKS GAEKQTPKDG SNKSGAEEQG PIDGPSKSGA EEQTSKDSPN KVVPEQPSRK DHSKPISNPS DNKELPKADT NQLADKGKLS PHAFKTESGE ETDLISPPQE EVKSSEPTED VEPKEAEDDD TGPEEGSPPK EEKEKMSGSA SSENREGTLS DSTGSEKDDL YPNGSGNGSA ESSHFFAYLV TAAILVAVLY IAHHNKRKII AFVLEGKRSK VTRRPKASDY QRLDQKS
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Background

TGOLN2 may be involved in regulating membrane traffic to and from trans-Golgi network.

References

Wu,C., et.al., Proteomics 7 (11), 1775-1785 (2007)
Honing,S., et.al., Mol. Cell 18 (5), 519-531 (2005)

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$ 162.50
$ 54.50
Cat# AP8955b
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