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pro Caspase 10 Antibody
Rabbit mAb
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, FC, ICC, IP |
|---|---|
| Primary Accession | Q92851 |
| Clonality | Monoclonal |
| Other Names | Apoptotic protease Mch4; CASP10; Caspase 10; FLICE2; ICE like apoptotic protease 4; FADD-like ICE2; |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Calculated MW | 58951 Da |
| Dilution | WB 1:500~1:1000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:10 FC 1:50 |
|---|---|
| Purification | Affinity-chromatography |
| Immunogen | A synthesized peptide derived from human pro Caspase 10 |
| Description | Caspases are a family of cytosolic aspartate specific cysteine proteases. Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaved Caspase 10 leads to the processing of Caspase 3 and Caspase 7, initiating a caspase cascade and subsequent apoptosis. |
| Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Name | CASP10 |
|---|---|
| Synonyms | MCH4 |
| Function | Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr- Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. |
| Tissue Location | Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 350.00
$ 175.00
Cat# AP90748
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