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EFEMP1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 5
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q12805 |
| Other Accession | O35568, Q8BPB5, Q7YQD7 |
| Reactivity | Human, Mouse |
| Predicted | Monkey, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 54641 Da |
| Antigen Region | 119-148 aa |
| Gene ID | 2202 |
|---|---|
| Other Names | EGF-containing fibulin-like extracellular matrix protein 1, Extracellular protein S1-5, Fibrillin-like protein, Fibulin-3, FIBL-3, EFEMP1, FBLN3, FBNL |
| Target/Specificity | This EFEMP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 119-148 amino acids from the N-terminal region of human EFEMP1. |
| Dilution | FC~~1:10~50 IHC-P~~1:50~100 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | EFEMP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EFEMP1 |
|---|---|
| Synonyms | FBLN3, FBNL |
| Function | Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. |
| Cellular Location | Secreted, extracellular space, extracellular matrix. Note=Localizes to the lamina propria underneath the olfactory epithelium {ECO:0000250|UniProtKB:O35568} |
| Tissue Location | In the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina |
Provided below are standard protocols that you may find useful for product applications.
Background
EFEMP1 encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors.
References
Okada,Y., et.al., Hum. Mol. Genet. (2010) In press
Wakabayashi,T., et.al., Biochem. Biophys. Res. Commun. 391 (1), 1116-1121 (2010)
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